Precision Medicine Role in Treating BRCA1

Precision medicine is one of the emerging approaches that is used in daily medical treatment extensions in the prevention and treatment of diseases with the consideration of the individual viability in the dimensions of unique gene characteristics, their environments as well as their preferred lifestyles. The aim of precision medicine is that it ought to present medical researchers and practitioners with the opportunity to evaluate and predict the most proper treatment and prevention methods that would fit a particular disease in response to a specific cohort or group of people. As opposed to the previous one-size-fits-all approach of medical treatment where a specific way of treatment would be used to help all average patients, precision medical treatment is more sensitive and considerate to the genetic and the environmental differences that surround individuals. In the United States of America and other developed countries, breast cancer is the second type of cancer in women with an approximated number of 12% of the women in the USA potential of developing breast cancer. Taking a focus on treatment strategies such as chemotherapy, surgery and platinum agents, this essay seeks to shed light on how precision medicines are continually being applied in treating breast cancer type BRCA1Precision Medicine Role in Treating BRCA1.

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Studies have established a number of differences between breast cancer and other types of cancers, and furthermore between different kinds of cancer and BRCA1 mutation.it has been found that women who are careers of the breast cancer mutation BRCA1 are more prevalent to acquiring other types of cancer either on the same breast or on their other chest (Godet & Gilkes, 2016;Breastcancer.org, 2019)). In such cases, women with a BRCA1 mutation are recommended for bilateral mastectomy, since the women with this type of breast cancer are less likely to succumb to breast cancer than when treated with the unilateral mastectomy which is the traditional surgery method for breast cancer. Bilateral is explicitly developed to address the BRCA1 type of breast cancer.

In medical therapy approaches, the most commonly used agents are the taxanes, which are agents that aid in microtubule stabilization to prevent cell proliferation. Commonly, docetaxel and paclitaxel taxanes have been continually used in treating breast cancer since the early 1990s (Maxwell & Domchek, 2012). However, since BRCA1 mutation has less response to taxanes when used in chemotherapy, research on genetic components have revealed that neoadjuvant chemotherapy could serve as a quick option for treating BRCA1 as compared to the traditional taxanes used. In the study, 46% of the total number of BRCA patients that participated in the study showed a positive pathological complete reaction to 22% that was revealed in other sporadic breast cancer types. Research has led to the establishment of anthracycline-taxane regimen for treating advanced stages of BRCA1 mutation.

Platinum agents, on the other hand, are agents that bind directly to the DNA of breast cancer patients intending to form adducts that eventually form DNA crosslinks and double o strand breaks. Earlier research had established a relationship between neoadjuvant chemotherapy types with enhanced recovery when using platinum agents in treating breast cancer. In more specialized research on BRCA associated breast cancer, it was established that BRCA1 mutations are more responsive to the cisplatin therapy therapeutic agent and may hence be used to introduce other subsets of cancer that are sensitive to cisplatin (Maxwell & Domchek, 2012). Following the research, RBCA1 reversion mutations are currently diagnosed for ripple negative breast cancer patients who have been developed for 18 weeks or less and has endured an approximated 18-20 weeks of platinum neoadjuvant agents as therapy Precision Medicine Role in Treating BRCA1.

In summary, following just but the few cases that are purely based on practical medicine research, precision medicine has proved to be beneficial strategy towards treating certain types of dreaded illnesses such as breast cancer in women. As opposed to traditional generalized types of therapy, precision medicine is a tool that is now widely applied to mitigate the symptoms of these diseases. As regarded above, treating BRCA1 have been made faster by using precise approaches in BRCA1 treatment methods such as incorrect chemotherapist agents, tailored surgery that is specific to BRCA1 as well as in the development of specifies platinum agents for handling BRCA1.

References

Breastcancer.org. (2019). Treatment and Side Effects. Retrieved from Breastcancer.org: https://www.breastcancer.org/treatment

Godet, I., & Gilkes, D. M. (2016). BRCA1 and BRCA2 mutations and treatment strategies for breast cancer. Oat Medical Journal, 1. doi:DOI: 10.15761/ICST.1000228

Maxwell, K. N., & Domchek, S. M. (2012). Cancer treatment according to BRCA1 and BRCA2 mutations. Nature Reviews Clinical Oncology pages 520–528 Precision Medicine Role in Treating BRCA1.

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